Cre driver lines

Cre-driver lines: A special type of transgenic mouse. As Cre-recombinase has no effect on DNA except for those that contain loxP sites (which are never found in mammalian DNA), generating transgenic Cre-recombinase mouse models was a logical step in examining specific expression of genetic tools (optogenetic, chemogenetic or other) in neurons. 98 rows · A cre recombinase coding sequence, driven by the mouse protamine 1 promoter (Prm) in . Tamoxifen Injection for Inducible Cre-Driver Lines. The JAX Cre Repository's aim is to provide the scientific community with a centralized, comprehensive set of well-characterized Cre Driver lines and related information resources. Available strains include Cre expressing strains, inducible Cre strains, Cre reporter strains, and loxP-flanked (floxed) strains.

Cre-driver lines: A special type of transgenic mouse Since Cre-recombinase has no effect on DNA except for those that contain loxP sites (which are never found in mammalian DNA), generating transgenic Cre-recombinase mouse models was a logical step in examining the specific expression of genetic tools (optogenetic, chemogenetic or other) in neurons. Cre-driver lines: A special type of transgenic mouse. As Cre-recombinase has no effect on DNA except for those that contain loxP sites (which are never found in mammalian DNA), generating transgenic Cre-recombinase mouse models was a logical step in examining specific expression of genetic tools (optogenetic, chemogenetic or other) in neurons. These Cre “driver” lines can be used to generate conditional mutations that are activated in distinct cell types, tissues or time points, or inducible mutations that are activated through administration of a drug. More than Cre driver lines have now been created and characterized, targeting selected neuronal populations in the brain.

However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for nervous system-specific. Jul One main advantage of systematic whole brain expression characterization across many Cre lines is the ability to identify both known and novel. Charles Gerfen), GENSAT offers transgenic BAC-Cre recombinase driver lines that allow for cell-specific gene manipulations in the central nervous system of the.